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4 edition of Induction of carcinoembryonic antigen expression in a three-dimensional culture system found in the catalog.

Induction of carcinoembryonic antigen expression in a three-dimensional culture system

Induction of carcinoembryonic antigen expression in a three-dimensional culture system

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Published by National Aeronautics and Space Administration, National Technical Information Service, distributor in [Washington, DC, Springfield, Va .
Written in English


Edition Notes

StatementJ.M. Jessup ... [et al.].
SeriesNASA TM -- 111144., NASA technical memorandum -- 111144.
ContributionsJessup, J. Milburn., United States. National Aeronautics and Space Administration.
The Physical Object
FormatMicroform
Pagination1 v.
ID Numbers
Open LibraryOL17793333M
OCLC/WorldCa34639266

To determine the relationship between carcinoembryonic antigen (CEA) expression in gastric cancer and biological behaviour or prognosis. Material and Methods: Surgically resected specimens of gastric cancer from patients were obtained. The content and distribution of CEA in gastric cancer were studied by immunohistochemical staining and immunoelectron microscopic technique. The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons. In humans it is clustered on the long arm of chromosome 19 and consists of approximately 20 genes.

Carcinoembryonic antigen (CEA) is a cell surface glycoprotein that functions as an intracellular adhesion molecule. It is physiologically expressed in the tissues during fetal development, but the expression ceases after birth []. However, its expression can be found in a wide variety of epithelial carcinomas, such as colon, stomach.   Carcinoembryonic antigen (CEA) expression has been shown to protect cancer cell lines from apoptosis and anoikis. The aim of this study was to further elucidate the role of CEA expression on resistance to anticancer drugs in human colorectal cancer (CRC). We transfected CEA negative CRC cell line SW as well as CHO cells to overexpress CEA and their chemoresistance .

Jessup JM, Brown D, Fitzgerald W, et al Induction of carcinoembryonic antigen expression in a three-dimensional culture system. In Vitro Cell Dev Biol Anim, -7, OpenUrl PubMed. Quantitative analysis of antigen for the induction of tolerance in carcinoembryonic antigen transgenic mice. T Hasegawa, K Isobe, I Nakashima, and K Shimokata First Department of Internal Medicine, Nagoya University School of Medicine, Japan.


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Induction of carcinoembryonic antigen expression in a three-dimensional culture system Download PDF EPUB FB2

Induction of carcinoembryonic antigen expression in a three-dimensional culture system Article (PDF Available) in In Vitro Cellular & Developmental Biology - Animal 33(5) June with. MIP is a poorly differentiated human colon carcinoma cell line established from ascites that produces minimal amounts of carcinoembryonic antigen (CEA), a kDa glycoprotein tumor marker, and nonspecific cross-reacting antigen (NCA), a related protein that has 50 and 90 kDa isoforms, in monolayer culture.

However, MIP produces CEA when implanted into the Cited by: Get this from a library. Induction of carcinoembryonic antigen expression in a three-dimensional culture system. [J Milburn Jessup; United States. National Aeronautics and Space Administration.;]. Induction of carcinoembryonic antigen expression in a three-dimensional culture system.

By R. Ford, A. Nachman is a poorly differentiated human colon carcinoma cell line established from ascites that produces minimal amounts of carcinoembryonic antigen (CEA), a kDa glycoprotein tumor marker, and nonspecific cross-reacting antigen.

human leukocyte antigen expression. Therefore, the highly differentiated I SI cell line and the poorly differentiated MIP cell line represent colorectal tumor cell types that are unresponsive to the ability of IFN-7 to induce alterations in tumor (i.e. CEA) or normal (i.e., class I and class II human leucocyte antigen) surface antigen.

Carcinoembryonic antigen family: expression in a mouse L-cell transfectant and characterization of a partial cDNA in bacteriophage lambda gt Proc Natl Acad Sci U S A. Aug; 84 (15)– [PMC free article] Oikawa S, Nakazato H, Kosaki G. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence.

little is known about the regulation of CEA expression. We show here that forced expression of SOX9, a novel intestinal crypt transcriptionfactor(10),inhibitsCEA gene expression and induces apoptosis in a human colon carcinoma cell line.

Materials and Methods Cell Culture. concept is based on recognition of a cell surface tumor antigen and simultaneous binding to the CD3 epsilon chain (CD3e) within the T-cell receptor (TCR) complex on T cells.

This triggers T-cell activation, including release of cytotoxic mole-cules, cytokines and chemokines, and induction. Carcinoembryonic antigen (CEA) has been reported to promote the metastatic potential in some experimental tumors. Adhesion molecules are known to play an important role in the process of metastasis.

Cytokines, including interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α), which are produced by Kupffer cells, induce endothelial cells to express adhesion molecules. The natural killer cell line, NKMI, is cytotoxic against various types of cancer.

The aim of this study was to develop chimeric antigen receptor-modified (CAR) NKMI cells targeting carcinoembryonic antigen-expressing (CEA) tumours and increase killing efficacy by pharmacologically modifying CEA-expression.

We generated anti-CEA-CAR NKMI cells by retroviral vector. Induction of carcinoembryonic-antigen expression in human colorectal carcinoma by sodium butyrate Article (PDF Available) in Biochemical Journal (2) January with 25 Reads. Expression of carcinoembryonic antigen and related genes in lung and gastrointestinal cancers.

Joohang Kim. NCI‐Navy Medical Oncology Branch, National Cancer Institute and Naval Hospital, Bethesda, MD. Search for more papers by this author. Frederic J. Kaye. Haiyen E. Zhau, Thomas J. Goodwin, Shi-Ming Chang, Tacey L.

Baker and Leland W. Chung, Establishment of a three-dimensional human prostate organoid coculture under microgravity-simulated conditions: Evaluation of androgen-induced growth and psa expression, In Vitro Cellular & Developmental Biology - Animal, /s, 33, 5.

Recently, carcinoembryonic antigen‐related cell adhesion molecule 6 (CEACAM6) has been reported to be a HER2‐related factor. The aim of the present study was to explore the therapeutic mechanism of trastuzumab, including the relevance of CEACAM6 expression.

Carcinoembryonic Antigen-Expressing Cancer. Carcinoembryonic antigen (CEA) is a cell surface glycoprotein that functions as an intracellular adhesion molecule. It is physiologically expressed in the tissues during fetal development, but the expression ceases after birth [].

Induction of carcinoembryonic antigen expression in a three-dimensional culture system. Article. structural formations and expression of carcinoembryonic antigen 7. Variety of cancer cells.

Human Lung Cancer Nodules in Organotypic Culture: No Evidence of Correlation between the Antiproliferative Effects of Interferons and the Induction of 2,5,igoadenylate Synthetase Martyre, M.-C; Beaupain, R.; Falcoff, E An Enzyme Immunoassay for Carcinoembryonic Antigen Which Employs Simultaneous.

J.M. Jessup, D. Brown, W. Fitzgerald, R.D. Ford, A. Nachman, T.J. Goodwin, G. Spaulding Induction of carcinoembryonic antigen expression in a three-dimensional culture system In vitro Cellular Developmental Biology—Animal, 33 (), pp.

Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nair SK(1), Boczkowski D.

Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Consequently, CEA is usually present at very low levels in the blood of healthy adults (about ng/mL).

However, the serum levels are raised in some types of cancer, which. Nair, S., Boczkowski, D., Morse, M. et al. Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA.Summary: This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells.

The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac.The regulation of carcinoembryonic antigen (CEA) expression by recombinant human interferon-gamma (IFN-gamma) was studied in a series of 7 human colorectal tumor cell lines at various stages of differentiation.

Two of the colorectal cell lines were poorly differentiated and did .